Describe in detail how inserti

Describe in detail how insertion, deletion, andbase substitution of nucleotides can have a significant impact ongenes. Find three specific examples(actualgene mutations, not chromosome mutations) of waysin which a very small change in DNA can have a major impact on anorganism, and describe each mutation in detail.


Insertion: In this mutation extra DNA basepairs are inserted into a new place or in the genes. The number ofbase pairs inserted can be one or many. Example: Huntington’sdisease in which nerve cells in the brain die and lead toinvoluntary movements, mental and cognitive abilities decreases.The Huntingtin gene codes a protein called ‘huntingtin’ which ishaving CAG (cytosine-adenine-guanine) triplet repeats, this repeatduplicates and expands producing more triplet inserts , resultingin abnormal protein folding leading to nerve cell damage

Deletions: In this mutation some part of geneor a length of nucleotides is deleted, it may range from one tothousands. Example: cri du chat (French for “cry of the cat”)syndrome, named for the distinctive cry affected infants make duein part to malformations of the larynx. Some part of three genesSemaphorine F (SEMA5A) and delta catenin (CTNND2), Telomerasereverse transcriptase, involved in cerebral development and larynxdevelopment   

Substitution: It’s a mutation where one basepair is replaced/substituted by another base pair, for example insickle cell anaemia disease, change in a “single letter code”(nitrogen base lets say on sense strand of DNA producing mRNA ifAdenine (A) is replaced by Thiamine (T)) results in change in acodon to one that encodes a different amino acid and cause a changein the protein produced. In Sickle Cell Anaemia codon GAG mutatesto GTG resulting in change in amino acids Glutamate to Valine,resulting in complete change in the folding pattern of haemoglobinand red blood cell acquires the shape of a ‘sickle’ instead ofconcave shape, which in turn affects oxygen carrying ability andpatients suffers from anaemia.

"Our Prices Start at $11.99. As Our First Client, Use Coupon Code GET15 to claim 15% Discount This Month!!"
Calculate the price
Make an order in advance and get the best price
Pages (550 words)
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Customer reviews in total
Current satisfaction rate
3 pages
Average paper length
Customers referred by a friend
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat

Sometimes it is hard to do all the work on your own

Let us help you get a good grade on your paper. Get professional help and free up your time for more important courses. Let us handle your;

  • Dissertations and Thesis
  • Essays
  • All Assignments

  • Research papers
  • Terms Papers
  • Online Classes