1. You are working in a hospit

1. You are working in a hospital and a patient was brought inwith purple rash covering their body. You need to explain to theothers that this patient has a Neisseria meningitidis bloodpoisoning. I. Explain the pathogenesis of the disease and what isthe virulence factor? II. How does the bacterium defend its selfagainst the immune system? III. How such a disease is to be treatedand why the use of this treatment method. IV. Explain why even withtreatment patient’s conditions may still worsen?


Pathogenesis of Neisseria meningitis:

  • Due to ethiloethol factors like bacteria with attack the liningbetween the brain and skull called the meninges.
  • Infected fluid from the meninges then passes into the spinalcord causing symptoms including stiff neck, fever and rashes.
  • The meninges begin to swell which affects the central nervoussystem.

Virulence factors includes

  1. Capsular polysaccharides.
  2. igA protease.
  3. Plasmids
  4. Fimloriae .
  5. Lipopolysaccharide
  6. Por A and por B protein
  7. Iron binding.

Bacterium defined it self aganisa immune system:

CD14 may sensitize the innate mucosal immune system to gramnegative bacteria which includes protection from specificpathogen.


3 generation broad spectrum antibiotics are

  • Cefotaxime
  • Benzyl pencillipe
  • Chloramphenicol
  • Cefotaxime

Support measures:

  • IV fluids
  • Oxigen
  • Inotropic support .ex- dopamine
  • Steroid therapy.

The patient condition still worsen because of Neisseriameningitis should receive IV antibiotics before result of lumberpuncture as delay in the treatment worsen the prognosis.

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